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Updated: Oct 7, 2025
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Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
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Granular Cell Tumor - An Important Entity to Consider on Upper Gastrointestinal Endoscopy
Mansi Oberoi1, Jacky Akhter2, Ashwyna Sunassee2
1Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
Summary
Granular cell tumors (GCTs) are rare esophageal lesions. Early diagnosis via endoscopy and biopsy is crucial for management and surveillance, as GCTs can rarely transform into malignant forms.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Granular cell tumors (GCTs) originate from neural or Schwann cells, commonly affecting the oral cavity, skin, and breast.
- While typically benign, GCTs can occur less frequently in the gastrointestinal tract, particularly the esophagus.
Observation:
- This report details two cases of esophageal GCTs identified during upper endoscopy (EGD).
- Diagnostic procedures included endoscopic ultrasound (EUS)-guided fine needle aspiration and biopsy of submucosal nodules.
- Histopathological examination confirmed GCT, supported by positive S100 immunostaining.
Findings:
- Esophageal GCTs present as submucosal nodules or lesions during EGD.
- Biopsies are essential for definitive diagnosis, with S100 staining aiding identification.
- GCTs are an important consideration in the differential diagnosis of esophageal abnormalities.
Implications:
- Prompt diagnosis of esophageal GCTs is vital for appropriate patient management.
- Although rare, the potential for malignant transformation necessitates surveillance.
- Regular endoscopic surveillance (EGD/EUS) every 2-3 years is recommended for unresected GCTs.
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