Related Experiment Video
Updated: Oct 7, 2025
05:53
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
16.7K
Predicting Frailty and Geriatric Interventions in Older Cancer Patients: Performance of Two Screening Tools for Seven
Claudia Martinez-Tapia1, Marie Laurent1,2, Elena Paillaud1,3
1Université Paris Est Créteil (UPEC), INSERM, IMRB, F-94010 Creteil, France.
Cancers
|January 11, 2022
Summary
The modified G8 screening tool demonstrates superior diagnostic performance compared to the G8 for identifying geriatric assessment impairments in older cancer patients. This enhanced tool aids in better patient selection for comprehensive geriatric oncology care.
Area of Science:
- Geriatric Oncology
- Clinical Assessment
- Screening Tools
Background:
- Geriatric assessment (GA) is crucial for older cancer patients but lacks standardization.
- Existing screening tools may not fully capture geriatric oncology practice nuances.
Purpose of the Study:
- To compare the diagnostic performance of the G8 and modified G8 screening tools.
- To evaluate these tools against multiple clinically relevant reference standards in geriatric oncology.
Main Methods:
- Retrospective analysis of 1136 cancer patients (≥ 70 years) from the ELCAPA cohort.
- Comparison of G8 and modified G8 performance using Area Under the Receiver Operating Characteristic Curve (AUROC) against various GA impairment and intervention metrics.
Main Results:
- Both G8 and modified G8 showed robust performance (AUROC ≥ 0.80) across all standards.
- The modified G8 demonstrated statistically significant higher AUROC values for six of seven reference standards, including detecting geriatric impairments and interventions.
Conclusions:
- The modified G8 exhibits superior diagnostic accuracy for identifying older cancer patients needing comprehensive geriatric assessment.
- Findings support the modified G8 as a more effective screening tool in geriatric oncology practice.
Related Concept Videos
01:15Drug Dosing: Geriatric Patients
12
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
12
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
6
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
6
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
14
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
14
01:21Cancer Survival Analysis
478
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
478
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
3
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
3
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
10
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
10