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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
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Atrial Fibrillation: Pathogenesis, Predisposing Factors, and Genetics.
Marios Sagris1, Emmanouil P Vardas1,2, Panagiotis Theofilis1
11st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
International Journal of Molecular Sciences
|January 11, 2022
Summary
Atrial fibrillation (AF) is a common heart rhythm disorder. Identifying modifiable risk factors like lifestyle and genetics is key to prevention and reducing healthcare costs.
Area of Science:
- Cardiology
- Preventive Medicine
- Genetics
Background:
- Atrial fibrillation (AF) is the most common cardiac arrhythmia, associated with significant mortality, stroke risk, and healthcare costs.
- Global prevalence estimates suggest up to 33.5 million individuals are affected by AF.
- Current treatments are effective but costly, highlighting the need for preventive strategies.
Purpose of the Study:
- To review predisposing factors for atrial fibrillation.
- To explore pathogenic mechanisms contributing to AF development.
- To identify modifiable risk factors for AF prevention and healthcare cost reduction.
Main Methods:
- Literature review of existing studies on atrial fibrillation.
- Analysis of pathogenic mechanisms including electrical and structural remodeling.
- Examination of lifestyle factors (sedentary behavior, diet) and genetic predispositions.
Main Results:
- AF development is linked to complex mechanisms like atrial tissue remodeling.
- Sedentary lifestyles and specific dietary habits are identified as contributing factors.
- Genetic predisposition plays a role in the susceptibility to AF.
Conclusions:
- Identifying and modifying risk factors for AF is crucial for public health and economic reasons.
- A comprehensive understanding of AF pathogenesis, including lifestyle and genetic influences, can guide preventive interventions.
- Targeting modifiable risk factors offers a promising approach to mitigate the burden of atrial fibrillation.
Keywords:
Mediterranean dietatrial fibrillationdietsgeneticsoxidative stresspathogenesispredisposing factorsMore Related Videos
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