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Updated: Oct 7, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

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Atrial Fibrillation: Pathogenesis, Predisposing Factors, and Genetics

Marios Sagris1, Emmanouil P Vardas1,2, Panagiotis Theofilis1

  • 11st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.

International Journal of Molecular Sciences
|January 11, 2022
PubMed

Insights

Atrial fibrillation (AF) is a common heart rhythm disorder. Identifying modifiable risk factors like lifestyle and genetics is key to prevention and reducing healthcare costs.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Genetics

Background:

  • Atrial fibrillation (AF) is the most common cardiac arrhythmia, associated with significant mortality, stroke risk, and healthcare costs.
  • Global prevalence estimates suggest up to 33.5 million individuals are affected by AF.
  • Current treatments are effective but costly, highlighting the need for preventive strategies.

Purpose of the Study:

  • To review predisposing factors for atrial fibrillation.
  • To explore pathogenic mechanisms contributing to AF development.
  • To identify modifiable risk factors for AF prevention and healthcare cost reduction.

Main Methods:

  • Literature review of existing studies on atrial fibrillation.
  • Analysis of pathogenic mechanisms including electrical and structural remodeling.
  • Examination of lifestyle factors (sedentary behavior, diet) and genetic predispositions.

Main Results:

  • AF development is linked to complex mechanisms like atrial tissue remodeling.
  • Sedentary lifestyles and specific dietary habits are identified as contributing factors.
  • Genetic predisposition plays a role in the susceptibility to AF.

Conclusions:

  • Identifying and modifying risk factors for AF is crucial for public health and economic reasons.
  • A comprehensive understanding of AF pathogenesis, including lifestyle and genetic influences, can guide preventive interventions.
  • Targeting modifiable risk factors offers a promising approach to mitigate the burden of atrial fibrillation.

Keywords:
Mediterranean dietatrial fibrillationdietsgeneticsoxidative stresspathogenesispredisposing factors

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