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Updated: Oct 7, 2025

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
Galectins in Early Pregnancy and Pregnancy-Associated Pathologies
Milica Jovanović Krivokuća1, Aleksandra Vilotić1, Mirjana Nacka-Aleksić1
1Institute for Application of Nuclear Energy Department for Biology of Reproduction, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
Abstract:
Galectins are a family of conserved soluble proteins defined by an affinity for β-galactoside structures present on various glycoconjugates. Over the past few decades, galectins have been recognized as important factors for successful implantation and maintenance of pregnancy. An increasing number of studies have demonstrated their involvement in trophoblast cell function and placental development. In addition, several lines of evidence suggest their important roles in feto-maternal immune tolerance regulation and angiogenesis. Changed or dysregulated galectin expression is also described in pregnancy-related disorders. Although the data regarding galectins' clinical relevance are still at an early stage, evidence suggests that some galectin family members are promising candidates for better understanding pregnancy-related pathologies, as well as predicting biomarkers. In this review, we aim to summarize current knowledge of galectins in early pregnancy as well as in pregnancy-related pathologies.
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