Related Experiment Video
Updated: Oct 7, 2025
10:21
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
565
Cysteinyl Leukotriene Pathway and Cancer
Ming-Ju Tsai1,2,3, Wei-An Chang1,2,3, Cheng-Hao Chuang1,4
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
International Journal of Molecular Sciences
|January 11, 2022
Summary
The cysteinyl leukotriene (CysLT) pathway, particularly via the CysLT1 receptor (CysLT1R), plays a significant role in cancer. Targeting CysLT1R shows promise in inhibiting cancer cell survival, progression, and chemoresistance.
Area of Science:
- Oncology
- Immunology
- Pharmacology
Background:
- Cancer remains a major global health challenge.
- Tumor microenvironment and immune dysregulation contribute to cancer.
- The cysteinyl leukotriene (CysLT) pathway has diverse biological functions.
Purpose of the Study:
- To summarize current findings on the CysLT pathway's role in cancer.
- To investigate the therapeutic potential of targeting the CysLT pathway in malignancies.
Main Methods:
- Review of in vitro and animal studies on CysLTs and cancer.
- Analysis of CysLT1 receptor (CysLT1R) expression in cancer tissues.
- Examination of retrospective cohort studies on CysLT1R antagonists.
Main Results:
- CysLTs promote cancer cell survival and proliferation via CysLT1R.
- CysLT1R antagonism reduced cancer cell vitality and induced apoptosis.
- CysLT1R antagonism demonstrated potential in reversing multidrug resistance.
- Animal studies showed CysLT1R antagonist efficacy in inhibiting tumorigenesis.
- CysLT1R expression correlated with poorer prognosis in colorectal and urological cancers.
- Retrospective studies indicated chemo-preventive effects of CysLT1R antagonists.
Conclusions:
- The CysLT pathway, mediated by CysLT1R, is implicated in various cancers.
- Targeting CysLT1R presents a potential therapeutic strategy for cancer treatment and prevention.
- Further research is warranted to fully elucidate the CysLT pathway's role in oncology.
Related Concept Videos
01:19Antiasthma Drugs: Leukotriene Modifiers
660
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
660
02:17The Tumor Microenvironment
6.9K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.9K
02:54Canonical Wnt Signaling Pathway
9.2K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
9.2K
01:41Non-Canonical Wnt Signaling Pathways
7.6K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.6K
01:23Cystic Fibrosis: Pathogenesis
390
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
390
01:26Asthma-II: Pathophysiology and Classification
3.3K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.3K