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A Review on the Role of miR-149-5p in the Carcinogenesis

Soudeh Ghafouri-Fard1, Tayyebeh Khoshbakht2, Bashdar Mahmud Hussen3

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran.

International Journal of Molecular Sciences
|January 11, 2022
PubMed

Insights

MicroRNA-149-5p (miR-149-5p) plays a dual role in cancer, acting as both an oncogene and tumor suppressor. This review explores its complex involvement in tumorigenesis across various cancers using in vitro, in vivo, and clinical data.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression.
  • miR-149, encoded by the MIR149 gene, produces two strands: miR-149-5p and miR-149-3p.
  • miR-149-5p has been implicated in various biological processes, including carcinogenesis.

Purpose of the Study:

  • To review the multifaceted roles of miR-149-5p in tumorigenesis.
  • To elucidate the mechanisms underlying miR-149-5p's involvement in cancer.
  • To consolidate evidence from in vitro, in vivo, and clinical studies.

Main Methods:

  • Literature review of studies investigating miR-149-5p in cancer.
  • Analysis of data from in vitro experiments (cell lines).
  • Analysis of data from in vivo models (animal studies) and clinical settings (patient data).

Main Results:

  • miR-149-5p exhibits both oncogenic and tumor-suppressive functions in different cancer types.
  • Evidence from diverse experimental settings supports its complex role in neoplastic conditions.
  • Specific mechanisms of action vary depending on the cellular context and cancer type.

Conclusions:

  • miR-149-5p is a significant player in cancer development and progression.
  • Understanding its dual role is crucial for developing targeted cancer therapies.
  • Further research is warranted to fully unravel its therapeutic potential.
Keywords:
biomarkercancerexpressionmiR-149-5pncRNAs

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