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Epigenetics of Cutaneous Sarcoma

Emi Mashima1, Yu Sawada1

  • 1Department of Dermatology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-Ku, Kitakyushu 807-8555, Japan.

International Journal of Molecular Sciences
|January 11, 2022
PubMed

Insights

Epigenetic modifications impact skin cancer development and progression. This review explores their role in cutaneous sarcomas and potential targeted therapies for these challenging skin cancers.

Area of Science:

  • Dermatology
  • Oncology
  • Epigenetics

Background:

  • Epigenetic alterations are crucial in various human diseases, including skin conditions.
  • Cutaneous sarcomas represent aggressive skin cancers with limited treatment options for advanced stages.

Purpose of the Study:

  • To review the molecular mechanisms of epigenetic modifications in specific skin sarcomas.
  • To explore the potential of epigenetic-targeted therapies for treating cutaneous sarcomas.

Main Methods:

  • Literature review of epigenetic studies related to skin sarcomas.
  • Analysis of molecular effects of epigenetic changes in dermatofibrosarcoma protuberans, angiosarcoma, Kaposi's sarcoma, leiomyosarcoma, and liposarcoma.

Main Results:

  • Epigenetic modifications play a significant role in the pathogenesis of various cutaneous sarcomas.
  • Specific epigenetic alterations are identified across different types of skin sarcomas.

Conclusions:

  • Understanding epigenetic mechanisms is key to developing novel therapeutic strategies for intractable skin sarcomas.
  • Epigenetic-targeted therapies offer promising avenues for managing advanced cutaneous sarcomas.
Keywords:
Kaposi’s sarcomaangiosarcomadermatofibrosarcoma protuberansepigeneticsleiomyosarcomaliposarcomaskin sarcoma

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