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The Endometrial Microbiome and Its Impact on Human Conception
Bruno Toson1, Carlos Simon2,3,4,5, Inmaculada Moreno2
1INCLIVA Biomedical Research Institute, Av. Menendez y Pelayo 4, 46010 Valencia, Spain.
International Journal of Molecular Sciences
|January 11, 2022
Summary
The uterine microbiome
Area of Science:
- Reproductive immunology
- Microbiome research
- Gynecology
Background:
- Genital tract microbiome alterations correlate with gynecological and obstetrical issues.
- Microbiome dysbiosis can negatively affect fertility treatment outcomes.
- The uterine cavity's core microbiome and its reproductive impact are debated due to study limitations.
Purpose of the Study:
- To review current knowledge on the uterine microbiota.
- To explore the relationship between the uterine microbiota and human conception.
- To highlight the potential for microbiome management in assisted reproductive therapies.
Main Methods:
- Literature review of existing studies on the uterine microbiome.
- Analysis of factors influencing endometrial bacterial community composition.
- Synthesis of evidence linking the microbiome to reproductive outcomes.
Main Results:
- A definitive consensus on the physiological uterine microbiome core is lacking.
- Variations in study design and sample size contribute to conflicting findings.
- The influence of endometrial bacteria on human reproduction requires further investigation.
Conclusions:
- Understanding the healthy endometrial microbiota is crucial for fertility.
- Personalized microbiome management could improve assisted reproductive therapy outcomes.
- Further research is needed to elucidate the precise role of the uterine microbiota in conception.
