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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

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Does Probiotic Consumption Enhance Wound Healing? A Systematic Review.

Camille Togo1, Ana Paula Zidorio1,2, Vivian Gonçalves3

  • 1Graduate Program in Human Nutrition, Faculty of Health Sciences, University of Brasilia, Campus Universitario Darcy Ribeiro, Brasilia 70910-900, Brazil.

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Summary

Probiotic therapy shows potential for improving wound healing, with some studies reporting positive outcomes and no adverse effects. Further controlled research is needed to confirm efficacy for skin and oral mucosal wound healing.

Keywords:
oral mucosal woundprobioticsskin woundsystematic reviewwound healing

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Dermatology

Background:

  • Probiotics are increasingly explored for therapeutic applications.
  • Wound healing is a complex biological process with various treatment modalities.
  • The role of probiotics in enhancing skin and oral mucosal wound healing requires further investigation.

Purpose of the Study:

  • To systematically review existing evidence on the efficacy of oral or enteral probiotic therapy for human skin or oral mucosal wound healing.
  • To assess the current level of scientific evidence regarding probiotic interventions for wound healing.
  • To identify trends and potential future research directions in this emerging field.

Main Methods:

  • A comprehensive literature search was conducted with no restrictions on wound type, population, probiotic strain, or protocol.
  • Seven studies involving 348 participants were included in the systematic review.
  • Data on healing outcomes and adverse effects were extracted and analyzed.

Main Results:

  • Four of the included studies reported positive effects of probiotic therapy on wound healing.
  • No studies reported significant adverse effects or increased wound healing times associated with probiotic use.
  • Observed results were generally positive or neutral, but did not constitute strong evidence of efficacy.

Conclusions:

  • Current evidence suggests probiotics may be a promising avenue for wound healing, particularly for skin and oral mucosal conditions.
  • The observed positive or neutral outcomes warrant further investigation with controlled clinical trials.
  • Future research should focus on specific probiotic strains, wound types, and target populations to establish definitive efficacy.