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Updated: Oct 7, 2025

In Vitro Phagocytosis of Myelin Debris by Bone Marrow-Derived Macrophages
Published on: December 30, 2017
Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins
Barbara Balestrieri1, David Di Costanzo1, Daniel F Dwyer1
1Department of Medicine, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Abstract:
Macrophages have diverse functions in the pathogenesis, resolution, and repair of inflammatory processes. Elegant studies have elucidated the metabolomic and transcriptomic profiles of activated macrophages. However, the versatility of macrophage responses in inflammation is likely due, at least in part, to their ability to rearrange their repertoire of bioactive lipids, including fatty acids and oxylipins. This review will describe the fatty acids and oxylipins generated by macrophages and their role in type 1 and type 2 immune responses. We will highlight lipidomic studies that have shaped the current understanding of the role of lipids in macrophage polarization.
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