Fecal Calprotectin Is Increased in Stroke.
Shin Young Park1, Sang Pyung Lee2, Woo Jin Kim1,3
1Department of Clinical Laboratory Science, Cheju Halla University, 38 Halladaehak-ro, Jeju-si 63092, Korea.
Journal of Clinical Medicine
|January 11, 2022
Summary
Increased fecal calprotectin (FC) indicates gut inflammation in stroke patients, correlating with consciousness and systemic inflammation markers like C-reactive protein (CRP). Further research is needed for FC
Area of Science:
- Neurology
- Gastroenterology
- Biochemistry
Background:
- Stroke remains a significant health burden despite advances in understanding central nervous system (CNS) mechanisms.
- Emerging research highlights the importance of peripheral changes and the brain-gut axis in stroke pathophysiology.
- Fecal calprotectin (FC) is a marker of gut inflammation.
Purpose of the Study:
- To evaluate gut inflammation, measured by FC, in stroke patients.
- To assess the association between FC levels and various blood variables in stroke patients.
Main Methods:
- Fecal samples were collected from 27 stroke patients and 27 controls.
- Fecal calprotectin (FC) was quantified using ELISA.
- Blood variables including CBC, ESR, glucose, creatinine, total protein, albumin, transaminases, and CRP were analyzed.
Main Results:
- Stroke patients exhibited significantly higher FC levels compared to controls.
- FC levels in stroke patients negatively correlated with the Glasgow Coma Scale (GCS).
- FC showed positive correlation with C-reactive protein (CRP) and negative correlation with lymphocyte count and albumin.
Conclusions:
- Elevated FC is linked to altered consciousness and systemic inflammatory responses in stroke.
- These findings suggest FC's potential role in understanding stroke-related systemic effects.
- Further investigation is warranted to explore FC's utility in stroke management.
