Conservative Surgery in Endometrial Cancer

Area of Science:

• Gynecologic Oncology
• Reproductive Endocrinology

Background:

• Endometrial cancer (EC) predominantly affects older women, but a subset of younger, nulliparous patients require fertility preservation.
• Standard treatment (hysterectomy) precludes future childbearing, necessitating alternative approaches for eligible patients.

Purpose of the Study:

• To review current fertility-sparing management options for endometrial cancer.
• To outline criteria, limitations, reproductive outcomes, and emerging trends in fertility-sparing EC treatment.

Main Methods:

• Literature review of studies on fertility-sparing treatments for endometrial cancer.
• Analysis of treatment approaches, response rates, recurrence, and pregnancy outcomes.

Main Results:

• Hysteroscopic resection followed by progestin therapy is an effective fertility-sparing option for EC.
• Achieved a 95.3% complete response rate, 14.1% recurrence rate, and 47.8% overall pregnancy rate (93.3% for those attempting conception).

Conclusions:

• Fertility-sparing management is a viable option for select young women with EC.
• Careful patient selection, counseling, and monitoring are essential for successful outcomes and reproductive health.