[Principles of differential pathogenesis-oriented therapy of various forms of osteopenia]

From the demonstration of etiopathogenetic mechanisms of osteopenia 7 different histologically and histomorphometrically defined pictures of the state (diseases) of the skeleton are derived. From this 4 different possibilities of the influence on the permanent transformation of the skeleton--the remodeling are the result. The medicamentous support of the blockade or stimulation of osteoclasts and the optimization of the mineralization are the basis of therapeutic considerations. In the light of these pathogenetically orientated treatment strategies the real and at present practicable therapy regimes of the various clinical manifestations of the osteopenia and new beginnings especially also of the therapy of osteoporosis are discussed.