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Updated: Oct 7, 2025
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Assessment of Social Transmission of Food Preferences Behaviors
Published on: January 25, 2018
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[Fish odor syndrome: A socially disabling disorder].
S Nicolas1, H Blasco2, A Bigot3
1Service de médecine interne, CHRU de Tours, Tours, France; Université de Tours, Tours, France.
La Revue De Medecine Interne
|January 11, 2022
Summary
Fish odor syndrome, a rare metabolic disorder, causes a "rotten fish" smell due to trimethylamine (TMA) excretion. A choline-restricted diet and digestive decontamination effectively reduced symptoms and improved patients' quality of life.
Area of Science:
- Metabolic disorders
- Genetics
- Human health
Background:
- Fish odor syndrome (FOS) is a rare metabolic disorder characterized by the excretion of trimethylamine (TMA) in bodily fluids, leading to a distinct
Observation:
- Two female patients presented with chronic, unpleasant body odor.
- Diagnosis was confirmed via NMR spectroscopy for trimethylaminuria and FMO3 gene analysis.
Findings:
- A treatment regimen involving a restrictive choline diet and digestive decontamination significantly reduced body odor.
- Patient quality of life and social interactions improved following treatment.
Implications:
- FOS is an underrecognized condition with significant psychosocial impact.
- Early laboratory diagnosis and targeted treatment can effectively manage FOS symptoms.
- Dietary modifications and decontamination offer a viable therapeutic strategy for FOS.
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