Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A genetic marker for rheumatic heart disease.

C N Rajapakse1, K Halim, I Al-Orainey

  • 1Department Medicine, King Saud University, Riyadh, Saudi Arabia.

British Heart Journal
|December 1, 1987
PubMed
Summary

The human leukocyte antigen DR4 (HLA-DR4) is significantly more common in patients with rheumatic heart disease and acute rheumatic fever. This finding suggests a potential link between HLA-DR4 and the development of these conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dobrin syndrome: A case report and review of the literature.

Indian journal of nephrology·2016
Same author

Obesity: an emerging problem in Saudi Arabia. Analysis of data from the National Nutrition Survey.

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit·2007
Same author

Behaviour and time-course of sleep disordered breathing in patients with acute coronary syndromes.

International journal of clinical practice·2005
Same author

Techniques for the removal of self-expanding metallic colorectal stents.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2004
Same author

Systemic inflammatory response syndrome (SIRS) from acute polyarticular gout.

The New Zealand medical journal·2000
Same author

Inpatient treatment of rheumatoid arthritis with synacthen depot: a double blind placebo controlled trial with 6 month followup.

The Journal of rheumatology·1999

Area of Science:

  • Immunogenetics
  • Rheumatology
  • Cardiovascular Disease

Background:

  • Rheumatic heart disease (RHD) and acute rheumatic fever (ARF) are significant global health concerns.
  • The genetic factors influencing susceptibility to RHD and ARF are not fully understood.
  • Previous studies have suggested a potential role for human leukocyte antigen (HLA) genes.

Purpose of the Study:

  • To investigate the frequency of specific HLA antigen types (A, B, C, and DR) in Saudi patients with RHD and ARF.
  • To compare HLA antigen frequencies between patients and healthy controls.
  • To explore the association between HLA-DR4 and the severity of valvular heart disease in RHD patients.

Main Methods:

  • A case-control study comparing HLA antigen frequencies.

Related Experiment Videos

  • Unselected groups of 25 patients with chronic RHD, 15 patients with ARF, and 100 healthy Arab volunteers of Saudi origin.
  • HLA typing for antigens A, B, C, and DR.
  • Analysis of HLA-DR4 frequency in relation to valvular lesions (mitral stenosis, aortic incompetence).

    • Main Results:

    • A significantly higher frequency of HLA-DR4 was observed in both RHD (72%) and ARF (53%) patient groups compared to healthy controls (12%).
    • The combined patient groups showed a 65% frequency of HLA-DR4, with a high relative risk (13.6).
    • HLA-DR4 was prevalent in RHD patients with mitral stenosis (83%) and aortic incompetence (70%).
    • Similar HLA-DR4 frequencies were found in non-Saudi Arab patients with RHD or ARF.

    Conclusions:

    • The study identifies a strong association between HLA-DR4 and susceptibility to ARF and RHD in the studied population.
    • HLA-DR4 may play a role in the pathogenesis of rheumatic fever and subsequent heart disease.
    • These findings warrant further investigation into the immunogenetic mechanisms underlying rheumatic fever and RHD.