Related Experiment Video
Updated: Oct 7, 2025
05:00
Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction
Published on: April 1, 2019
15.2K
A multi-center study evaluating the correlation between meibomian gland dysfunction and depressive symptoms.
Zhenyu Wei1, Junqi Liang1,2, Kai Cao1
1Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, 100005, China.
Scientific Reports
|January 11, 2022
Summary
Depression is more common in patients with meibomian gland dysfunction (MGD). Conditions like obstructive sleep apnea-hypopnea syndrome (OSAHS) and contact lens wear increase depression risk in MGD patients.
Area of Science:
- Ophthalmology
- Psychiatry
- Public Health
Background:
- Meibomian gland dysfunction (MGD) is increasingly linked to depression.
- Specific risk factors for depression in MGD patients require further investigation.
Purpose of the Study:
- To determine the prevalence of depression in MGD patients.
- To identify risk factors associated with depression in this population.
Main Methods:
- Multi-center cross-sectional study involving 830 MGD patients and 114 controls.
- Data collection included questionnaires on lifestyle, medical history, and ophthalmic examinations.
- Depression symptoms assessed using a modified self-rating depression scale (M-SDS).
Main Results:
- Depression prevalence was 9.4% in MGD patients versus 3.5% in controls.
- MGD patients exhibited higher M-SDS scores, with crying spells, sleep disturbance, and appetite changes being common.
- Hyperlipidemia and obstructive sleep apnea-hypopnea syndrome (OSAHS) were more prevalent in the MGD group.
Conclusions:
- MGD is associated with a higher prevalence of depression.
- Systemic conditions (OSAHS, allergies, skin disease) and contact lens use are risk factors for depression in MGD patients.
Related Concept Videos
01:27Depressive Disorders: MDD and Dysthymia
234
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
234
01:27Depressive Disorders: Etiology
181
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
181
01:03Long-term Depression
2.7K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.7K
01:18Depression: Overview
414
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
414