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COVID-19 and chronic kidney disease: an updated overview of reviews

Sara S Jdiaa1, Razan Mansour2, Abdallah El Alayli2

  • 1Division of Nephrology, University of Toronto, Toronto, ON, Canada.

Journal of Nephrology
|January 11, 2022
PubMed

Insights

Chronic Kidney Disease (CKD) significantly increases the risk of hospitalization and mortality in patients with COVID-19. Identifying preventative strategies for this vulnerable population is crucial.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Public Health

Background:

  • Coronavirus disease (COVID-19) has caused over 3.5 million deaths globally.
  • Comorbidities, such as Chronic Kidney Disease (CKD), significantly impact COVID-19 outcomes.
  • This study assesses the effect of CKD on COVID-19 contraction, hospitalization, mortality, and severity.

Purpose of the Study:

  • To evaluate the impact of Chronic Kidney Disease (CKD) on COVID-19 outcomes.
  • To synthesize evidence on CKD's association with COVID-19 hospitalization, mortality, and severity.
  • To inform preventative strategies for individuals with CKD.

Main Methods:

  • An overview of systematic reviews and primary studies was conducted.
  • Searches included published and preprint databases, with updates for studies post-August 2020.
  • Review quality was assessed using the AMSTAR tool.

Main Results:

  • Sixty-nine systematic reviews and 66 primary studies were included.
  • Prevalence of CKD in COVID-19 patients ranged from 0.4% to 49.0%.
  • CKD was associated with increased hospitalization (RR=1.63) and mortality (HR=1.48, OR=1.77) in COVID-19 patients.

Conclusions:

  • Chronic Kidney Disease (CKD) is linked to adverse outcomes in COVID-19 patients.
  • There is a critical need for targeted prevention strategies for COVID-19 in individuals with CKD.
Abstract

Keywords:
COVID–19Chronic kidney disease (CKD)HospitalizationMortalitySARS–CoV–2

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