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Deoxygenative Cross-Coupling of Aromatic Amides with Polyfluoroarenes

Youliang He1, Yuxiao Wang1, Shi-Jun Li2

  • 1State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.

Angewandte Chemie (International Ed. in English)
|January 11, 2022
PubMed
Summary

This study introduces a new method for synthesizing alpha-polyfluoroaryl amines using aromatic amides and polyfluoroarenes. This deoxygenative cross-coupling reaction offers a versatile strategy for creating diverse organofluorine compounds.

Keywords:
AmidesC−H FunctionalizationPolyfluoroarenesPolyfluoroarylationα-Aminocarbene

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