Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

12.6K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
12.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ROS produced in mitochondria entrapped by self-assembly peptide fibers for target therapy of glioma.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Shape-Dependent Self-Assembled Targeting Peptide Electrosensitizer for Enhanced Radiofrequency Ablation of Lipid-Rich Atherosclerotic Plaques.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same author

Living Inorganic Nanomaterials: Design, Preparation, and Biomedical Applications.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Conformationally Variable Peptides Trap and Detoxify Ox-LDL in Plaques for Attenuating Atherosclerosis in Multiple Species.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Targeting and self-assembling peptides mimic fibrinogen coagulation for alleviating hypofibrinogenemia.

Biomaterials science·2026
Same author

In Situ Peptide Self-Assembly Augments Antibody Recruitment for Tumor Immunotherapy.

Advanced materials (Deerfield Beach, Fla.)·2026

Related Experiment Video

Updated: Oct 7, 2025

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.1K

Self-Assembled Peptide Drug Delivery Systems.

Jia Yang1,2, Hong-Wei An1,2, Hao Wang1,2

  • 1CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, P.R. China.

ACS Applied Bio Materials
|January 11, 2022
PubMed
Summary

Self-assembled peptide nanomaterials offer promising solutions for drug delivery, enhancing targeting and reducing toxicity. These advanced biomaterials show potential for intelligent nanomedicine and clinical applications.

Keywords:
drug deliverynanofibrilsnanomaterialnanoparticlespeptideself-assembly

More Related Videos

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.4K
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.5K

Related Experiment Videos

Last Updated: Oct 7, 2025

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.1K
Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.4K
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.5K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Nanomaterials have advanced biomedical applications like bioimaging and drug delivery.
  • Peptides offer biocompatibility, design flexibility, and self-assembly for nanomaterial construction.

Purpose of the Study:

  • To review design strategies for self-assembled peptide nanomaterials in drug delivery.
  • To highlight the potential of peptide-based nanomedicines.

Main Methods:

  • Summarized three design strategies: ex situ construction, in situ morphological transformation, and in situ construction of peptide drug delivery systems (PDDs).
  • Discussed drug loading via physical encapsulation or chemical conjugation.

Main Results:

  • Peptide nanomaterials demonstrate enhanced drug retention at tumor sites, increasing drug uptake.
  • Drug-free peptide nanomaterials can also function as nanomedicines.

Conclusions:

  • Self-assembled peptides hold significant promise for intelligent nanomedicine.
  • These peptide-based nanomaterials show potential for clinical translation in drug delivery.