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[Sensitivity of clinical Proteus strains to antibiotics and their combinations]

E P Sheina, A A Arutcheva

    Antibiotiki
    |May 1, 1978
    PubMed

    Insights

    Proteus bacteria, common in wound infections, show high resistance to many antibiotics. Gentamicin, furagin, and nevigramone offer some effectiveness, with specific drug combinations showing promise for treatment.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Clinical Pharmacy

    Background:

    • Proteus species are significant pathogens in purulent wound infections.
    • In 1976, Proteus accounted for 14.5% of isolates from wound infections, with serotypes O-10, O-3, and H-3 being predominant.
    • Understanding antibiotic resistance patterns in Proteus is crucial for effective treatment.

    Purpose of the Study:

    • To assess the antibiotic susceptibility of clinical Proteus isolates.
    • To evaluate the efficacy of various antibiotic combinations against Proteus strains.

    Main Methods:

    • Susceptibility testing of 35 clinical Proteus strains against 10 antibiotics, furagin, and nevigramone using serial dilutions in liquid media.
    • Evaluation of the effectiveness of 14 different chemotherapeutic combinations.

    Main Results:

    • Most Proteus isolates exhibited high resistance to common antibiotics.
    • Gentamicin, furagin, and nevigramone showed notable activity, with minimum inhibitory concentrations (MICs) of 3.12 µg/ml, 1.6–3.12 µg/ml, and 6.25–12.5 µg/ml, respectively.
    • Combinations of gentamicin with carbenicillin, gentamicin with ampicillin, and monomycin with ampicillin were most effective.

    Conclusions:

    • Proteus strains demonstrate significant antibiotic resistance.
    • Specific antibiotic combinations, including gentamicin-carbenicillin, gentamicin-ampicillin, and monomycin-ampicillin, show practical therapeutic value.
    • Further investigation into combinations like ampicillin-furagin and gentamicin-furagin is warranted for rational therapeutic strategies.

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