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Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Although all next-generation methods use different technologies, they all share a set of standard features....
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Direct Motor Pathways01:11

Direct Motor Pathways

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The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
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Indirect Motor Pathways01:22

Indirect Motor Pathways

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The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
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DNA Helicases00:55

DNA Helicases

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DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
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Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

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In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
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Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

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Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
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Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
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Recent Progress in DNA Motor-Based Functional Systems.

Bini Zhou1, Yuanchen Dong2, Dongsheng Liu1

  • 1Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, PR China.

ACS Applied Bio Materials
|January 11, 2022
PubMed
Summary
This summary is machine-generated.

DNA motors offer versatile, stimuli-responsive designs for creating functional systems. These DNA motors generate mechanical power and advance smart devices, particularly in drug delivery and molecular switching applications.

Keywords:
DNA motorsDNA nanotechnologybiomedical applicationsmolecular machinessmart materials

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Area of Science:

  • Biotechnology and Nanotechnology
  • Materials Science

Background:

  • DNA's inherent designability, functionalization capabilities, and diverse secondary structures facilitate the creation of responsive DNA motors.
  • DNA motors are engineered to respond to various external stimuli, including pH, light, heat, electrical, and chemical signals.

Purpose of the Study:

  • To review and discuss recent advancements in the construction of DNA motor-based functional systems.
  • To highlight the diverse applications of DNA motors in smart devices and materials.

Main Methods:

  • Literature review of recent progress in DNA motor research.
  • Analysis of DNA motor applications in responsive nanodevices, modified surfaces, and hydrogels.

Main Results:

  • DNA motors enable the fabrication of functional systems and the generation of mechanical power.
  • Applications include controllable drug delivery and reversible molecular switching.
  • DNA motors are integral to the development of advanced smart devices and responsive materials.

Conclusions:

  • DNA motors represent a powerful platform for developing sophisticated, stimuli-responsive functional systems.
  • Continued research promises further innovation in nanodevices, materials science, and biomedical applications.