Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The relationship between biocompatibility and interleukin-1.

S Shaldon1, C A Dinarello

  • 1Department of Nephrology, University Hospital, Nimes, France.

Life Support Systems : the Journal of the European Society for Artificial Organs
|October 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical, hematologic, and immunologic effects of interleukin-10 in humans.

Journal of clinical immunology·1996
Same author

Protein metabolism in rheumatoid arthritis and aging. Effects of muscle strength training and tumor necrosis factor alpha.

Arthritis and rheumatism·1996
Same author

Effect of endotoxin in IL-1 beta-deficient mice.

Journal of immunology (Baltimore, Md. : 1950)·1996
Same author

Modulation of osteoclast-activating factor activity of multiple myeloma bone marrow cells by different interleukin-1 inhibitors.

Experimental hematology·1996
Same author

Thermoregulation and the pathogenesis of fever.

Infectious disease clinics of North America·1996
Same author

Three distinct promoters direct transcription of different 5' untranslated regions of the human interleukin 1 type I receptor: a possible mechanism for control of translation.

Cytokine·1996
Same journal

Biocompatibility testing of membrane plasmapheresis devices.

Life support systems : the journal of the European Society for Artificial Organs·1987
Same journal

Complement activation and leucopenia on cellulosic haemodialyzers: influence of the membrane area and role of hydroxyl moieties.

Life support systems : the journal of the European Society for Artificial Organs·1987
Same journal

Side effects and mortality associated with plasma exchange: a three year experience with a regional register.

Life support systems : the journal of the European Society for Artificial Organs·1987
Same journal

Dynamic cardiomyoplasty: a new approach to assist chronic myocardial failure.

Life support systems : the journal of the European Society for Artificial Organs·1987
Same journal

Counterpulsation in atrio-aortic bypass: theoretical and experimental aspects.

Life support systems : the journal of the European Society for Artificial Organs·1987
Same journal

A new method of continuous haemoglobinometric measurement of blood volume during haemodialysis.

Life support systems : the journal of the European Society for Artificial Organs·1987
See all related articles

Extracorporeal procedures trigger inflammatory responses by stimulating Interleukin-1 (IL-1) production. This can lead to serious complications like bone cysts and joint fibrosis, necessitating urgent solutions.

Area of Science:

  • Biomedical Engineering
  • Immunology
  • Nephrology

Background:

  • Biocompatibility is redefined as mutual tolerance with life.
  • Extracorporeal and invasive procedures can trigger the body's inflammatory defense mechanisms.
  • Interleukin-1 (IL-1) is a key mediator in the inflammatory response.

Purpose of the Study:

  • To explore the mechanisms by which extracorporeal procedures stimulate Interleukin-1 (IL-1) production.
  • To identify the consequences of chronic IL-1 stimulation.
  • To highlight the need for strategies to mitigate these adverse effects.

Main Methods:

  • Review of existing literature on biocompatibility and inflammatory responses.
  • Identification of IL-1 inducers present in extracorporeal circuits (dialysate, bacterial products, complement activation).

Related Experiment Videos

  • Correlation of IL-1 stimulation with clinical complications.

    • Main Results:

    • IL-1 production is stimulated by components in dialysate (bacterial pyrogen, acetate) and bacterial cell wall fragments (muramyl peptides).
    • Activation of the complement system (C5a) also induces IL-1 production.
    • Chronic IL-1 stimulation is linked to muscle wasting, osteopenia, bone cysts, joint fibrosis, and carpal-tunnel syndrome.

    Conclusions:

    • Extracorporeal procedures initiate a cascade leading to IL-1 production and acute phase response.
    • Adverse outcomes such as "Shrinking man syndrome" and amyloidosis are associated with repeated IL-1 stimulation.
    • Urgent research and clinical efforts are needed to reduce these complications.