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Updated: Oct 7, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Rhodium-Catalyzed C-H Methylation and Alkylation Reactions by Carbene-Transfer Reactions
Claire Empel1, Sripati Jana1, Tim Langletz1
1Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074, Aachen, Germany.
Abstract:
In this combined computational and experimental study, the C-H functionalization of 2-phenyl pyridine with diazoalkanes was investigated. Initial evaluation by computational methods allowed the evaluation of different metal catalysts and diazoalkanes and their compatibility in this C-H functionalization reaction. With these findings, suitable reaction conditions for the C-H methylation reactions were quickly identified by using highly reactive TMS diazomethane and C-H alkylation reactions with donor/acceptor diazoalkanes, which is applied to a broad scope on alkylation reactions of 2-aryl pyridines with TMS diazomethane and donor/acceptor diazoalkane (51 examples, up to 98 % yield).
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