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Updated: Oct 7, 2025

Parametric Optimization Design Method for Friction Plates of Hydro-Viscous Clutches
Published on: July 22, 2025
Fine-tuning CARs for best performance
Alastair Hotblack1, Karin Straathof1
1University College London (UCL) Great Ormond Street Institute of Child Health, London, UK; UCL Cancer Institute, London, UK.
Abstract:
Chimeric antigen receptors (CARs) allow redirection of T cells against any surface antigen. However, CARs require optimization to achieve activity against low-density antigens. Heitzeneder et al. perform an iterative adjustment of CAR components to reach a design for targeting cerebroglycan (GPC2) that shows potent pre-clinical activity in neuroblastoma models.
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