Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement and dengue haemorrhagic fever/shock syndrome.

P Malasit1

  • 1Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

The Southeast Asian Journal of Tropical Medicine and Public Health
|September 1, 1987
PubMed
Summary

The complement system, crucial for immunity, is activated during Dengue Hemorrhagic Fever/Dengue Shock Syndrome (DHF/DSS), contributing to shock and leakage. Its activation correlates with disease severity, suggesting a key role in DHF/DSS pathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complement alternative pathway genetic variation and Dengue infection in the Thai population.

Clinical and experimental immunology·2013
Same author

Construction of infectious dengue 2 virus cDNA clones using high copy number plasmid.

Journal of virological methods·2001
Same author

Autosomal recessive distal renal tubular acidosis associated with Southeast Asian ovalocytosis.

Kidney international·1999
Same author

Distal renal tubular acidosis and high urine carbon dioxide tension in a patient with southeast Asian ovalocytosis.

American journal of kidney diseases : the official journal of the National Kidney Foundation·1999
Same author

Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis.

Journal of immunology (Baltimore, Md. : 1950)·1998
Same author

Renal tubular function in beta-thalassemia.

Pediatric nephrology (Berlin, Germany)·1998

Area of Science:

  • Immunology
  • Pathophysiology
  • Virology

Background:

  • Dengue Hemorrhagic Fever/Dengue Shock Syndrome (DHF/DSS) is a severe manifestation of dengue virus infection.
  • The complement system plays a vital role in immune responses but can also contribute to inflammatory diseases.

Purpose of the Study:

  • To investigate the role of complement system activation in the pathogenesis of DHF/DSS.
  • To determine the correlation between complement activation products and disease severity.

Main Methods:

  • Assay of complement activation products (C3a, C5a) in patient serum.
  • Assessment of disease severity and presence of shock and leakage.
  • Detection of circulating immune complexes using standard techniques.

Related Experiment Videos

Main Results:

  • Complement activation was observed in DHF/DSS patients.
  • Peak complement activation and presence of C3a and C5a correlated with shock and leakage onset.
  • C3a levels showed a strong correlation with DHF/DSS disease severity.

Conclusions:

  • The complement system plays a significant role in the pathogenesis of shock in DHF/DSS.
  • Circulating immune complexes were not consistently detected, suggesting other mechanisms may drive complement activation.
  • Further investigation into alternative complement activation pathways in DHF/DSS is warranted.