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Multiple Physically Cross-Linked F127-α-CD Hydrogels: Preparation, Sol-Gel Transformation, and Controlled Release of
Peihong Li1, Chunling Zhang1, Rui Li1
1Key Laboratory of Automobile Materials, Ministry of Education, College of Materials Science and Engineering, Jilin University, Changchun 130022, P.R. China.
Abstract:
Pluronic F127 is a thermosensitive polymer that has been extensively studied and utilized in biomedicine. To improve the gelation properties of F127, α-cyclodextrin was introduced by physical interactions, such as forming inclusion complexes, hydrogen bond self-assembly, and hydrophobic interactions, to prepare F127-α-CD hydrogels. This study explored the temperature-dependent sol-gel transition behavior, gelation mechanism, interior morphology, and controlled release of the anticancer drug 5-fluorouracil. Results showed that hydrogel could be obtained at 1.0%-8.0% weight content of F127. The cross-linking points in this system were PEO-α-CD microcrystalline region and micelle with poly(propylene oxide) as the core. The network inside F127-α-CD hydrogels made it stable and conducive for controlled release. Therefore, this hydrogel is a promising drug release system.
