129Xe Hyper-CEST/19F MRI Multimodal Imaging System for Sensitive and Selective Tumor Cells Detection
Huaibin Zhang1,2, Shizhen Chen1, Yaping Yuan1
1State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, National Center forMagnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.
ACS Applied Bio Materials
|January 12, 2022
Summary
This study introduces a novel dual-nuclei MRI method combining hyperpolarized Xenon-129 (129Xe) and Fluorine-19 (19F) for precise tumor detection and localization. This advanced imaging system enhances molecularly targeted agent visualization in cancer diagnosis and therapy.
Area of Science:
- Medical Imaging
- Biomedical Engineering
- Molecular Imaging
Background:
- Heteronuclear MRI shows promise for detecting and quantifying targeted agents in diagnostics and therapy.
- Current methods require further development for sensitive and selective tumor cell detection.
Purpose of the Study:
- To develop a novel method for simultaneous dual-nuclei (129Xe and 19F) MRI for tumor targeting.
- To create an integrated imaging system for sensitive and selective tumor cell detection and anatomical localization.
Main Methods:
- Developed a simultaneous dual-nuclei hyper-CEST 129Xe and 19F MRI acquisition method.
- Integrated 129Xe hyper-CEST MRI, 19F MRI, and fluorescent imaging into a perfluorooctyl bromide (PFOB) nanoemulsion system.
- Utilized the system for sensitive and selective tumor cell detection and anatomical localization.
Main Results:
- Successfully demonstrated simultaneous acquisition of dual-nuclei 129Xe and 19F MRI signals.
- The integrated PFOB nanoemulsion system achieved sensitive and selective tumor cell detection.
- 129Xe and 19F signals provided efficient and precise anatomical tumor localization, complementing 1H MRI.
Conclusions:
- The novel dual-nuclei MRI method enables simultaneous acquisition of 129Xe and 19F signals for enhanced tumor targeting.
- The integrated imaging system offers sensitive tumor detection and precise localization, advancing molecularly targeted imaging applications.
- This approach complements conventional 1H MRI, improving diagnostic and therapeutic capabilities.
