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Correlation between abnormal thyroid function test and thyroid autoimmunity: a systematic review and meta-analysis
Ning Xiao1, Yingying Li1, Wangjin Chen1
1Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
Background:
This study was to analyze the correlation between abnormal thyroid function detection and thyroid autoimmune disease, so as to provide theoretical guidance for clinical diagnosis of thyroid autoimmune disease.
Methods:
The Chinese databases were searched with a combination of words "thyroid", "thyroid autoimmune disease", "thyroid function testing", "meta-analysis". The entire database was searched in English language databases with the search terms "thyroid", "thyroid autoimmune disease", "thyroid function test ", "meta-analysis". Review manager software was applied for meta-analysis.
Results:
A total of 8 articles were finally included. 4 articles reported the T3 level, showing P=0.95, I2=0%, odds ratio (OR) =2.39, 95% confidence interval (CI): 0.79-7.25; 3 articles reported the T4 levels, showing P=0.81, I2=0%, OR =2.16, 95% CI: 0.43-10.71; and 4 articles reported the thyroid stimulating hormone (TSH) level, showing P=0.48, I2=0%, OR =3.20, 95% CI: 1.45-7.07.
Discussion:
After a systematic review of the literature, a significant difference was found in T3 and TSH levels between patients with autoimmune thyroid disease and those with a healthy thyroid, but the difference in T4 level was not significant.
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