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Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

Increased expression of T helper 17 cells and interleukin-17 in atopic dermatitis: a systematic review and

Yujie Mao¹, Chao Yang¹, Lina Tang¹

¹Institute of Dermatology and Venereology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China.

Annals of Palliative Medicine

|January 12, 2022

Abstract

Background:

Atopic dermatitis (AD) is a chronic inflammatory skin disease with genetic susceptibility and recurrent attacks. Research examining the etiology of this disease has mainly focused on environmental factors and immunity, with immune disorders believed to be the main factor in the occurrence and development of AD. While some studies have demonstrated that increased proportion of T helper 17 (Th17) cells in the lesions of specific dermatitis mouse models, the expression of Th17 cells and interleukin (IL)-17 in patients with AD remains controversial.

Methods:

Related literatures were retrieved from English databases including PubMed, Embase, and Ovid-Medline. Literatures published from the establishment of the database to April 2021 were identified using the following keywords: AD, T helper cell 17 (Th17 cell), and interleukin 17 (IL-17). Review Manager5.3 software was adopted for meta-analysis.

Results:

A total of 8 studies, involving 1,147 subjects, related to the pathogenesis of AD were included in this meta-analysis. The analysis revealed that the expression of Th17 cells in patients with AD was higher than that in healthy patients (P<0.00001), and the serum expression of IL-17 was also elevated in patients with AD compared to healthy participants (P=0.0001).

Discussion:

A total of 8 publications related to the pathogenesis of AD were analyzed. The meta-analysis found that patients with AD had higher expressions of Th17 cells and IL-17 compared to healthy subjects, suggesting that AD may be related to Th17 cells and IL-17.

Keywords:

Atopic dermatitis (AD)T helper cell 17 (Th17 cell)correlation interleukin 17 (IL-17)meta-analysis

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