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Related Experiment Videos

Autoimmunity in psoriasis. A complement immunofluorescence study.

E H Beutner, M Jarzabek-Chorzelska, S Jablonska

    Archives of Dermatological Research
    |April 7, 1978
    PubMed
    Summary
    This summary is machine-generated.

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    Stratum corneum (SC) antibodies are found in human sera and bind to psoriatic lesions, fixing complement. This suggests SC antibodies and complement play a role in psoriasis development.

    Area of Science:

    • Immunology
    • Dermatology
    • Autoimmunity

    Background:

    • Stratum corneum (SC) antibodies are ubiquitously present in human sera.
    • These antibodies have been observed to bind to the SC in vivo, particularly in psoriatic lesions.

    Purpose of the Study:

    • To investigate the presence and role of SC antibodies and complement fixation in psoriatic lesions.
    • To determine the extent of complement deposition in various types of psoriatic lesions.

    Main Methods:

    • Indirect immunofluorescent (IF) staining of human sera and psoriatic scales.
    • Two-step complement IF test system utilizing anti-C4 and anti-C3 conjugates.
    • Analysis of complement deposition in fully developed and fresh linear psoriatic lesions.

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    Main Results:

    • SC antibodies were detected in all human sera tested.
    • In psoriatic lesions, SC antigens were coated with IgG and, in most cases, complement.
    • Complement was detected in 88% of fully developed lesions and 50% of fresh linear lesions.

    Conclusions:

    • SC antibodies and complement fixation are indirectly implicated in the pathogenesis of psoriasis.
    • Findings support the hypothesis that an autoimmune response involving SC antibodies contributes to psoriasis development.