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Aminoacyl-tRNA Synthetases, Indispensable Players in Lung Tumorigenesis

Pratyasha Bhowal1, Priyanka Biswas Karmakar1, Debkanya Dey1

  • 1Department of Biotechnology, Dr. B.C. Guha Centre for Genetic Engineering and Biotechnology, Faculty of Science, University of Calcutta, Kolkata, India.

Protein and Peptide Letters
|January 12, 2022
PubMed

Insights

Aminoacyl-tRNA synthetases (aaRSs) and AIMPs form complexes involved in lung cancer. This review explores their roles in tumorigenesis and potential as novel therapeutics for lung cancer treatment.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Oncology

Background:

  • Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes for protein synthesis with conserved functions.
  • Emerging research reveals non-canonical roles for aaRSs and associated proteins (AIMPs) beyond protein synthesis.
  • These proteins form a multi-tRNA synthetase complex (MSC), implicating them in various cellular processes.

Purpose of the Study:

  • To review the structure and function of the multi-tRNA synthetase complex (MSC).
  • To elucidate the involvement of aaRSs and AIMPs in the maintenance and progression of lung cancer.
  • To discuss the molecular mechanisms underlying their roles in lung tumorigenesis.

Main Methods:

  • Literature review focusing on studies investigating aaRSs, AIMPs, and lung cancer.
  • Analysis of the structural organization of the MSC.
  • Examination of molecular pathways implicated in lung tumorigenesis involving these protein complexes.

Main Results:

  • aaRSs and AIMPs play crucial roles in regulating lung cancer.
  • Evidence suggests their involvement in both the initiation and progression of lung tumorigenesis.
  • Specific molecular mechanisms of action within lung cancer cells are being uncovered.

Conclusions:

  • The aaRS-AIMPs complex has significant implications in lung cancer regulation.
  • These proteins represent promising therapeutic targets for novel lung cancer treatments.
  • Further research into the MSC could lead to advanced therapeutic strategies for lung tumorigenesis.
Keywords:
AIMPsAminoacyl-tRNA synthetases (aaRSs)MSCinhibitorslung cancersignal pathways

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