Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

1.5K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.5K
Autoimmune Disorders01:29

Autoimmune Disorders

781
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
781
What is the Immune System?01:38

What is the Immune System?

118.3K
Overview
118.3K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.0K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.0K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

756
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
756
Inflammatory Response01:28

Inflammatory Response

10.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
10.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enpatoran, a Toll-like receptor 7/8 inhibitor, in moderate-to-severe systemic lupus erythematosus: findings from Cohort B of a multicentre, international, double-blind, placebo-controlled dose-finding phase 2 trial.

Lancet (London, England)·2026
Same author

Lectin pathway of complement in SLE: MAP-1 as a marker of haematological manifestations and elevated type I interferon activity.

Lupus science & medicine·2026
Same author

Enpatoran, a first-in-class, selective, orally administered toll-like receptor 7/8 inhibitor, in systemic and cutaneous lupus erythematosus: results from a randomised, placebo-controlled phase Ib study.

Lupus science & medicine·2025
Same author

Co-Occurrence of Endometriosis with Systemic Lupus Erythematosus: Genetic Aspects.

International journal of molecular sciences·2025
Same author

Co-occurrence of endometriosis with psoriasis and psoriatic arthritis: Genetic insights (Review).

Experimental and therapeutic medicine·2025
Same author

Role of interleukin-16 in human diseases: a novel potential therapeutic target.

Frontiers in immunology·2025
Same journal

Reducing plastic waste in skin-model research: Sustainable packaging as a practical first step.

The Journal of investigative dermatology·2026
Same journal

Modern serum proteomics in precision medicine: Toward disease stratification and predictive, proactive treatment strategies.

The Journal of investigative dermatology·2026
Same journal

An Integrated Skin Cell Atlas Decodes the Pilosebaceous Unit.

The Journal of investigative dermatology·2026
Same journal

Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

The Journal of investigative dermatology·2026
Same journal

Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

The Journal of investigative dermatology·2026
Same journal

Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris.

The Journal of investigative dermatology·2026
See all related articles

Related Experiment Video

Updated: Oct 7, 2025

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

13.5K

Type I Interferons in Autoimmunity.

Ruth Fernandez-Ruiz1, Timothy B Niewold2

  • 1Division of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA.

The Journal of Investigative Dermatology
|January 12, 2022
PubMed
Summary
This summary is machine-generated.

Dysregulated interferon-1 (IFN-1) responses are key in autoimmune diseases like lupus. Elevated IFN-1 levels correlate with disease severity and may predict treatment response to targeted therapies.

More Related Videos

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
08:26

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Published on: June 14, 2018

12.1K
Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice
08:43

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice

Published on: January 31, 2020

7.0K

Related Experiment Videos

Last Updated: Oct 7, 2025

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

13.5K
Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
08:26

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Published on: June 14, 2018

12.1K
Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice
08:43

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice

Published on: January 31, 2020

7.0K

Area of Science:

  • Immunology
  • Autoimmunity
  • Molecular Biology

Background:

  • Interferon-1 (IFN-1) signaling is integral to immune function.
  • Dysregulated IFN-1 pathways are implicated in the pathogenesis of various autoimmune diseases.
  • Elevated IFN-1 activity is observed in conditions such as lupus, systemic sclerosis, Sjogren's syndrome, and dermatomyositis.

Purpose of the Study:

  • To review the signaling pathways and immune functions of IFN-1 in both healthy and diseased states.
  • To discuss systemic autoimmune diseases associated with increased IFN-1.
  • To summarize current therapeutic strategies targeting the IFN-1 system.

Main Methods:

  • Literature review of scientific publications on IFN-1.
  • Analysis of the role of IFN-1 in autoimmune disease development and progression.
  • Synthesis of information on therapeutic interventions targeting IFN-1.

Main Results:

  • IFN-1 signaling is a critical factor in multiple autoimmune conditions.
  • Enhanced IFN-1 activity is linked to disease severity and autoantibody production.
  • IFN-1 levels may serve as a biomarker for predicting treatment outcomes.

Conclusions:

  • Understanding IFN-1 pathways is crucial for managing autoimmune diseases.
  • Targeting IFN-1 offers promising therapeutic avenues for patients with autoimmune disorders.
  • Further research into IFN-1 modulation could lead to improved treatment strategies.