Cost-effective analysis of automated programming optimization in cardiac resynchronization therapy: Holistic Markov
Takashi Noda1, Xiaoxiao Lu2, Yoko Ishiguro2
1Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
Journal of Cardiology
|January 12, 2022
Summary
Automated optimization algorithm (AdaptivCRT) for cardiac resynchronization therapy (CRT) improves patient survival and reduces healthcare costs in Japan. This adaptive CRT technology offers significant economic benefits and better outcomes.
Area of Science:
- Cardiology
- Health Economics
- Medical Technology
Background:
- Automated optimization algorithms for cardiac resynchronization therapy (CRT), such as AdaptivCRT, have been developed.
- The cost-effectiveness of AdaptivCRT in clinical practice remains largely unexamined.
Purpose of the Study:
- To evaluate the potential economic benefits and cost-effectiveness of AdaptivCRT in a Japanese healthcare setting.
Main Methods:
- Markov modeling was employed, utilizing data from the AdaptivCRT Clinical Trial.
- Published meta-analyses informed the model regarding hospitalization and mortality risks based on clinical composite scores.
- Economic impact was assessed by comparing costs and survival rates between adaptive and conventional CRT.
Main Results:
- AdaptivCRT demonstrated a projected mean survival of 10.97 years compared to 10.5 years for conventional CRT.
- Modeled heart failure hospitalization costs were lower with AdaptivCRT (US $12,686) versus previous technology (US $13,989).
- Sensitivity analyses indicated cost savings across all scenarios with AdaptivCRT.
Conclusions:
- AdaptivCRT is projected to enhance average patient survival in Japan.
- The implementation of AdaptivCRT is expected to lead to significant cost avoidance within the Japanese healthcare system.
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