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Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and

Stephanie Cerceo Page1, Srinidhi Rao Sripathy1, Federica Farinelli1

  • 1Lieber Institute for Brain Development, Baltimore, MD 21205.

Proceedings of the National Academy of Sciences of the United States of America
|January 12, 2022
PubMed

Keywords:
electrophysiologyschizophreniasodium channelstem cell

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...