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Cryo-electron Microscopy01:28

Cryo-electron Microscopy

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Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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Related Experiment Video

Updated: Oct 7, 2025

Single-Particle Cryo-EM Data Collection with Stage Tilt using Leginon
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A dynamic direction for cryo-EM

Allison Doerr1

  • 1Nature Methods, . a.doerr@us.nature.com.

Nature Methods
|January 12, 2022
PubMed
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No abstract available in PubMed .

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