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Various Assisted Bone Regeneration in Apicectomy Defects Systematic Review and Meta Analysis
Ananad Sumangali1, Rahul V C Tiwari2, Jeevana Kollipara3
1Department of Endodontics, Sebha Dental College, University of Sebha, Sebha, Libya, North Africa.
Journal of Pharmacy & Bioallied Sciences
|January 12, 2022
Summary
Regenerative endodontic surgery significantly improves outcomes in apicectomy procedures. Combining materials like autologous platelet concentrates and collagen membranes yields better results than using them alone for bone regeneration.
Area of Science:
- Endodontics
- Regenerative Medicine
- Oral Surgery
Background:
- Endodontic surgery frequently employs regenerative methods for root end cutting or apicectomy.
- The success of apicectomy is influenced by surgical technique and biomaterials used.
- Persistent periapical lesions often necessitate regenerative approaches.
Purpose of the Study:
- To systematically review and meta-analyze assisted bone regeneration techniques in endodontic apicectomy defects.
- To evaluate the efficacy of various regenerative materials and combinations.
Main Methods:
- A comprehensive online search of databases including PubMed, Scopus, Web of Science, and Google Scholar was performed.
- Included studies focused on regenerative procedures for persistent periapical lesions.
- Clinical and radiographic outcomes were compared between regenerative surgery (case) and control groups; risk of bias was assessed.
Main Results:
- Eleven studies were included in the meta-analysis from 1561 initially identified articles.
- Regenerative endodontic surgery significantly improved outcomes compared to controls.
- Autologous platelet concentrates or collagen membranes alone showed good outcomes, while their combination demonstrated significantly better results than individual applications.
Conclusions:
- Regenerative procedures are demonstrably beneficial for endodontic apicectomy.
- The choice and combination of biomaterials significantly augment treatment outcomes.
- Combining regenerative materials offers a superior prognosis for apicectomy defects.
