Quadruple Score: A Novel Scoring System for Diagnosing Breast Lump - A Retrospective Pilot Study

Area of Science:

• Oncology
• Radiology
• Pathology

Background:

• The triple test is a sensitive breast cancer screening method but has limitations.
• A novel quadruple score was developed to enhance initial breast cancer screening.
• This score integrates physical examination, ultrasound, mammography, and fine-needle aspiration cytology (FNAC).

Purpose of the Study:

• To evaluate the sensitivity, specificity, and predictive values of the new quadruple score.
• To assess the diagnostic accuracy of the quadruple score in initial breast cancer screening.
• To compare the quadruple score's performance against individual diagnostic methods.

Main Methods:

• A retrospective study of 320 patients with breast lumps was conducted.
• Data from physical examination, ultrasound, mammography, and FNAC were collected.
• A cumulative Quadruple Test Score (QTS) was calculated and validated against histopathology.

Main Results:

• The quadruple score demonstrated a strong linear correlation (0.9996) between its components.
• The accuracy of the QTS was found to be 99.44%.
• The QTS showed higher accuracy compared to individual diagnostic methods.

Conclusions:

• The Quadruple Test Score (QTS) is a precise and dependable method for breast lump evaluation.
• Implementing the QTS can streamline the management of palpable breast lumps.
• This scoring system offers a universal platform for managing discordant diagnostic results.