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Saleh Mayoof Al-Osaimi1, Althumali Abdulaziz Hameed2, Atheer Abdulraheem Alsufyani3

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Summary

This case report details a rare olfactory neuroblastoma (ONB) in a young female, successfully treated with surgery and radiotherapy. It highlights the importance of prolonged surveillance for this rare nasal malignancy.

Keywords:
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Area of Science:

  • Oncology
  • Otorhinolaryngology
  • Neurosurgery

Background:

  • Olfactory neuroblastoma (ONB), also known as esthesioneuroblastoma, is a rare cancer originating in the upper nasal vault.
  • Management of ONB is often challenging due to its rarity and limited literature, leading to non-standardized treatment approaches.

Observation:

  • A 27-year-old female presented with a two-year history of nasal obstruction, sneezing, nasal discharge, and left eye protrusion.
  • The patient was diagnosed with olfactory neuroblastoma.

Findings:

  • The patient underwent successful treatment combining endoscopic sinus surgery and adjuvant radiotherapy (RT).
  • A 5-year follow-up confirmed successful management with no recurrence, suggesting feasibility and effectiveness of this treatment protocol.

Implications:

  • This case underscores the necessity of prolonged surveillance for ONB due to its potential for late recurrence.
  • Endoscopic resection followed by adjuvant radiotherapy presents a viable and effective treatment strategy for olfactory neuroblastoma.
  • This report represents the first documented case of ONB in Saudi Arabia, contributing valuable data to the existing literature.