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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Related Experiment Video

Updated: Oct 7, 2025

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Refined Residual Deep Convolutional Network for Skin Lesion Classification.

Khalid M Hosny1, Mohamed A Kassem2

  • 1Department of Information Technology, Faculty of Computers and Informatics, Zagazig University, Zagazig, Egypt. k_hosny@yahoo.com.

Journal of Digital Imaging
|January 12, 2022
PubMed
Summary
This summary is machine-generated.

A new residual deep convolutional neural network (RDCNN) accurately diagnoses skin lesions. This advanced model significantly outperforms existing deep learning methods for skin cancer classification.

Keywords:
ClassificationDeep convolution neural networkResidual learningSkin lesions

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Area of Science:

  • Dermatology
  • Artificial Intelligence
  • Medical Imaging

Background:

  • Skin cancer is the most common human cancer, often diagnosed via clinical screening and dermoscopy.
  • Automated skin lesion classification is challenging due to visual similarities between melanoma and benign lesions.

Purpose of the Study:

  • To propose a novel residual deep convolutional neural network (RDCNN) for improved skin lesion diagnosis.
  • To evaluate the performance of the proposed RDCNN across multiple benchmark skin cancer datasets.

Main Methods:

  • The RDCNN was trained and tested on six datasets: PH2, DermIS and Quest, MED-NODE, ISIC2016, ISIC2017, and ISIC2018.
  • Three experiments were conducted: training on original images, testing on segmented images, and transfer learning using a pre-trained model.

Main Results:

  • The proposed RDCNN demonstrated high performance in classifying skin lesions.
  • The RDCNN model achieved superior results compared to existing deep convolutional networks.

Conclusions:

  • The developed RDCNN offers a promising approach for automated skin lesion diagnosis.
  • The RDCNN's effectiveness is validated across diverse datasets and experimental conditions.