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An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
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Adiponectin: a pleiotropic hormone with multifaceted roles
S S Shklyaev1, G A Melnichenko2, N N Volevodz2
1National Research Center for Endocrinology of the Ministry of Health of the Russian Federation; A. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation.
Problemy Endokrinologii
|January 12, 2022
Summary
Adiponectin, a key hormone from fat tissue, offers protective benefits like improved insulin sensitivity and reduced inflammation. However, low levels are linked to diseases, including COVID-19 respiratory failure, creating a complex
Area of Science:
- Endocrinology
- Metabolic research
- Physiology
Background:
- Adipose tissue functions as a major endocrine organ, secreting adipokines.
- Adiponectin is the most abundant adipokine, known for diverse physiological roles.
- Its functions are primarily studied in rodent models.
Purpose of the Study:
- To review the multifaceted roles of adiponectin.
- To elucidate the mechanisms of adiponectin action in health and disease.
- To discuss the implications of adiponectin in various pathological conditions.
Main Methods:
- Literature review of existing studies on adiponectin.
- Analysis of evidence from animal and human studies.
- Synthesis of information on adiponectin's physiological and pathological relevance.
Main Results:
- Adiponectin exhibits insulin-sensitizing, anti-diabetic, anti-obesity, anti-inflammatory, anti-atherogenic, cardio-protective, and neuro-protective effects.
- Reduced adiponectin levels are implicated in conditions like COVID-19-associated respiratory failure.
- The 'adiponectin paradox' highlights its complex role in systemic diseases and malignancies.
Conclusions:
- Adiponectin plays critical roles in metabolic homeostasis and possesses significant protective properties.
- Understanding adiponectin's dual role is crucial for addressing various diseases.
- Further research is needed to fully comprehend its mechanisms and therapeutic potential.
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