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Related Experiment Video

Updated: Oct 7, 2025

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

Adiponectin: a pleiotropic hormone with multifaceted roles.

S S Shklyaev¹, G A Melnichenko², N N Volevodz²

¹National Research Center for Endocrinology of the Ministry of Health of the Russian Federation; A. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation.

Problemy Endokrinologii

|January 12, 2022

Summary

Adiponectin, a key hormone from fat tissue, offers protective benefits like improved insulin sensitivity and reduced inflammation. However, low levels are linked to diseases, including COVID-19 respiratory failure, creating a complex

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Last Updated: Oct 7, 2025

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

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Published on: May 4, 2021

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Area of Science:

Endocrinology
Metabolic research
Physiology

Background:

Adipose tissue functions as a major endocrine organ, secreting adipokines.
Adiponectin is the most abundant adipokine, known for diverse physiological roles.
Its functions are primarily studied in rodent models.

Purpose of the Study:

To review the multifaceted roles of adiponectin.
To elucidate the mechanisms of adiponectin action in health and disease.
To discuss the implications of adiponectin in various pathological conditions.

Main Methods:

Literature review of existing studies on adiponectin.
Analysis of evidence from animal and human studies.
Synthesis of information on adiponectin's physiological and pathological relevance.

Main Results:

Adiponectin exhibits insulin-sensitizing, anti-diabetic, anti-obesity, anti-inflammatory, anti-atherogenic, cardio-protective, and neuro-protective effects.
Reduced adiponectin levels are implicated in conditions like COVID-19-associated respiratory failure.
The 'adiponectin paradox' highlights its complex role in systemic diseases and malignancies.

Conclusions:

Adiponectin plays critical roles in metabolic homeostasis and possesses significant protective properties.
Understanding adiponectin's dual role is crucial for addressing various diseases.
Further research is needed to fully comprehend its mechanisms and therapeutic potential.