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Key considerations and common adverse events for HIV-positive patients with cancer treated with immune checkpoint
Emre Yekedüz1,2, Güngör Utkan1,2, Yüksel Ürün1,2
1Department of Medical Oncology, Ankara University, Ankara 06590, Turkey.
Abstract:
HIV-infected patients are more susceptible to cancer due to their immune-compromised condition and HIV infection. Chronic inflammation and immune dysregulation are the main causes of cancer development in these patients. Because of lymphopenia and an immune-compromised condition, most HIV-infected patients with cancer were not considered for cytotoxic therapies, such as chemotherapy and radiotherapy. Immune checkpoint inhibitors (ICIs) have become a game-changer in many cancer types. However, not enough prospective data is available regarding the use of ICIs in HIV-infected patients with cancer. Retrospective data from case reports/series showed that ICIs are safe in HIV-infected patients with cancer.
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