GASTROINTESTINAL COMPLICATIONS OF CORONAVIRUS DISEASE (COVID-19)
Marcelo Augusto Fontenelle Ribeiro-Junior1,2,3, Samara de Souza Augusto4, Yasmin Garcia Batista Elias4
1Disciplina de Cirurgia Geral e do Trauma, Pontifícia Universidade Católica de São Paulo, Sorocaba, SP, Brasil.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can infect the gastrointestinal tract due to high angiotensin-converting enzyme 2 (ACE2) expression. This review highlights gastrointestinal complications for early COVID-19 diagnosis and treatment.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Virology
Background:
- Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters cells via angiotensin-converting enzyme 2 (ACE2) receptors.
- Tissues with high ACE2 expression, including the gastrointestinal tract, are susceptible to SARS-CoV-2 infection.
- Atypical COVID-19 manifestations and diagnostic challenges necessitate exploring gastrointestinal complications.
Purpose of the Study:
- To review and synthesize the literature on gastrointestinal complications associated with COVID-19.
- To emphasize the role of the gastrointestinal tract in SARS-CoV-2 infection and its clinical implications.
Main Methods:
- A narrative synthesis approach was used for qualitative data analysis.
- Literature search conducted in PubMed, Medline, and SciELO databases using the term "Gastrointestinal complication of COVID".
Main Results:
- Analysis included 28 articles (primarily case reports/series), two retrospective cohorts, and one case-control study.
- Identified gastrointestinal complications include hemorrhagic, thrombotic, ischemic, and perforation events.
- Other reported complications encompass acute pancreatitis and pneumatosis intestinalis.
Conclusions:
- High ACE2 expression in the gastrointestinal tract correlates with increased SARS-CoV-2 susceptibility.
- Recognizing gastrointestinal manifestations is crucial for early COVID-19 diagnosis and management.
- Prompt identification and treatment of gastrointestinal symptoms can prevent severe outcomes and mortality.
More Related Videos
07:59Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
Published on: September 10, 2021
08:07Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery
Published on: October 4, 2024
Related Concept Videos
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:23Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
01:30Other Disorders of Digestive System
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:28Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations: