Amphiphilic Block Copolymers-Guided Strategies for Assembling Nanoparticles: From Basic Construction Methods to...

Area of Science:

• Polymer Science
• Materials Science
• Nanotechnology

Background:

• Amphiphilic block copolymers (ABCs) are extensively studied for self-assembling into nanoparticles (NPs).
• These ABC-based NPs are of significant interest for controlled delivery of drugs, genes, proteins, and imaging agents.
• Their unique physical and biological properties make them highly attractive for biomedical applications.

Purpose of the Study:

• To review and summarize optimized preparation techniques for fabricating drug-loaded NPs from ABCs.
• To analyze parameters of various techniques and highlight improvements for co-loading diverse bioactive agents.
• To guide researchers in selecting appropriate methods for designing advanced drug delivery systems.

Main Methods:

• Emulsification and solvent evaporation
• Double emulsification and solvent evaporation
• Nanoprecipitation
• Film dispersion

Main Results:

• Four primary techniques for NP fabrication were categorized and analyzed.
• Proper technique selection enables incorporation of various bioactive agents, alone or in combination.
• Improved techniques allow simultaneous co-loading of hydrophilic/hydrophobic drugs and nucleic acids into single NPs.

Conclusions:

• Optimized fabrication techniques are crucial for developing effective ABC-based nanoparticle drug delivery systems.
• The reviewed methods provide a framework for designing NPs capable of delivering multiple therapeutic agents.
• These advancements facilitate the creation of sophisticated nanomedicines for targeted therapies.