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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Oct 7, 2025

Designing a Bio-responsive Robot from DNA Origami

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

Designer, Programmable 3D DNA Nanodevices to Probe Biological Systems.

Anjali Rajwar¹, Sumit Kharbanda¹, Arun Richard Chandrasekaran²

¹Biological Engineering Discipline, Indian Institute of Technology Gandhinagar, Palaj, Gujarat 382355, India.

ACS Applied Bio Materials

|January 12, 2022

Summary

DNA nanotechnology enables self-assembling nanodevices for biomedical uses. This review highlights 3D DNA nanocages for cellular programming, biosensing, and targeted therapies, discussing future challenges and opportunities.

Keywords:

3D cages bioimaging biomedical applications structural DNA nanotechnology targeted delivery

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Last Updated: Oct 7, 2025

Designing a Bio-responsive Robot from DNA Origami

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Area of Science:

Biomedical Engineering
Nanotechnology
Molecular Biology

Background:

DNA nanotechnology offers robust design for self-assembling nanoarchitectures.
The field has evolved from creating structures to developing functional DNA nanodevices.
Three-dimensional (3D) DNA nanocages are a key focus for advanced applications.

Purpose of the Study:

To provide an overview of DNA nanotechnology strategies.
To focus on the construction and applications of 3D DNA nanocages.
To discuss the potential of 3D DNA nanodevices in modulating cellular systems, biosensing, and targeted therapeutics.

Main Methods:

Review of DNA nanotechnology principles.
Summarization of construction strategies for DNA nanodevices.
Focus on 3D nanocage designs, particularly tetrahedral DNA cages.

Main Results:

DNA nanotechnology facilitates the creation of functional nanodevices.
3D DNA nanocages demonstrate potential in programming cellular systems.
Applications include biosensing and targeted therapeutic delivery.

Conclusions:

3D DNA nanocages are promising for diverse biomedical applications.
Further research is needed to address challenges and explore future perspectives.
DNA nanodevices offer innovative tools for biological exploration and intervention.