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Related Experiment Video

Updated: Oct 7, 2025

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
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Biodegradable Breast Tissue Marker Clip.

Moran Haim Zada1, Zehava Gallimidi2, Michal Schlesinger Laufer3

  • 1Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.

ACS Applied Bio Materials
|January 12, 2022
PubMed
Summary
This summary is machine-generated.

New biodegradable biopsy clips offer a safe, effective alternative to metal markers for visualizing breast tumor regions. These advanced tissue markers are visible across multiple imaging types and show excellent biocompatibility in animal studies.

Keywords:
biodegradable polymer clipsbreast tumorscontrast agentsimaging techniquesin vivo visibility

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Area of Science:

  • Biomaterials Science
  • Medical Imaging
  • Oncology

Background:

  • Metal-based biopsy markers can cause imaging artifacts and patient discomfort.
  • There is a need for biocompatible, easily visualized tissue markers for tumor detection.

Purpose of the Study:

  • To develop and evaluate biodegradable soft tissue biopsy clips as visual markers for tumor regions.
  • To assess the biocompatibility and imaging characteristics of these novel clips.

Main Methods:

  • Biodegradable polymers (poly(l-lactide-co-ε-caprolactone), methoxy polyethylene glycol-co-l-lactide) with contrast agents (iodixanol, barium sulfate) were used.
  • Clips were coated with hyaluronic acid or sodium alginate hydrogels.
  • Implantation in Sprague-Dawley rats followed by evaluation using mammography, ultrasound, and MRI, alongside histopathological examination.

Main Results:

  • The biodegradable clips were clearly visible via mammography, ultrasound, and MRI post-implantation.
  • Clips remained intact for over 3 months with minimal changes in length and morphology.
  • Histopathological analysis showed no systemic toxicity in the rats.

Conclusions:

  • Developed biodegradable biopsy clips demonstrate excellent biocompatibility and imaging properties.
  • These clips show potential as a safe and effective replacement for traditional metal-based markers in breast tumor visualization.