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Tailored Biofunctionalized Biosensor for the Label-Free Sensing of Prostate-Specific Antigen
Sachin Mishra1,2, Eun-Seong Kim2, Parshant Kumar Sharma2
1NDAC Centre, Kwangwoon University, Nowon-gu, Seoul 01897, South Korea.
ACS Applied Bio Materials
|January 12, 2022
Summary
Researchers developed a novel capacitive biosensor for rapid, selective detection of prostate-specific antigen (PSA). This affordable, miniaturized device offers ultrafast, reproducible, and reusable PSA quantification for point-of-care applications.
Area of Science:
- Biomarker detection
- Biosensor technology
- Point-of-care diagnostics
Background:
- Growing demand for smart biosensors drives innovation in biomarker detection.
- Prostate-specific antigen (PSA) is a key biomarker requiring sensitive detection methods.
Purpose of the Study:
- To develop a miniaturized, capacitive biosensor for rapid and selective prostate-specific antigen (PSA) detection.
- To create an affordable biodevice for daily life applications and point-of-care diagnostics.
Main Methods:
- Fabrication of an interdigitated capacitor (IDC) biosensor functionalized for PSA detection.
- Utilizing capacitive response to biomolecular interactions for signal generation.
- Testing PSA detection across concentrations from 0.1 to 10 μL/mL.
Main Results:
- Achieved ultrafast PSA detection with a response time of 3 seconds.
- Demonstrated high selectivity for PSA detection via probing capacitive responses.
- Exhibited excellent reproducibility and reusability of the IDC-based biosensor.
Conclusions:
- The developed capacitive biosensor enables direct, rapid, and selective PSA quantitation.
- The biosensor's performance is suitable for low-concentration detection in point-of-care settings.
- This research opens opportunities for advanced PSA detection and other biomarker applications.
