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Nrf2/ARE axis signalling in hepatocyte cellular death

Bayan Y Ghanim1, Nidal A Qinna2,3

  • 1Faculty of Pharmacy and Medical Sciences, University of Petra Pharmaceutical Center (UPPC), University of Petra, Amman, Jordan.

Molecular Biology Reports
|January 12, 2022
PubMed

Insights

The Nrf2-ARE pathway is vital for cellular defense against liver injury. This review explores its role in various hepatocyte cell death modes, offering insights into therapeutic strategies.

Area of Science:

  • Cellular Biology
  • Hepatology
  • Molecular Mechanisms

Background:

  • The Nrf2-ARE pathway regulates cellular defense and redox balance.
  • Hepatocyte injury and death are central to liver diseases.
  • The precise role of Nrf2 in diverse cell death pathways remains incompletely understood.

Purpose of the Study:

  • To review the current understanding of the Nrf2-ARE pathway's involvement in various hepatocyte cell death mechanisms.
  • To highlight the crosstalk between Nrf2 signaling and cell death pathways.
  • To provide a perspective on Nrf2 as a critical regulator of hepatocyte fate.

Main Methods:

  • Literature review of scientific articles on Nrf2, ARE, and hepatocyte cell death.
  • Analysis of signaling networks and molecular mechanisms.
  • Synthesis of current research findings.

Main Results:

  • Nrf2-ARE signaling is implicated in multiple hepatocyte cell death modes, including apoptosis, necrosis, ferroptosis, and pyroptosis.
  • Cross-talk exists between Nrf2 and key cellular execution pathways.
  • Nrf2 plays a critical role in determining cell survival versus cell death outcomes.

Conclusions:

  • Understanding the Nrf2-ARE axis's interaction with cell death pathways is crucial for liver disease research.
  • Targeting Nrf2 signaling offers potential therapeutic avenues for liver pathologies.
  • Further research into Nrf2's multifaceted role can improve treatment strategies.
Keywords:
AutophagyFerroptosisNF-κBPPARγPyroptosisSREBF1

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