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Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
Published on: February 26, 2019
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Human Gastrointestinal Transit and Hormonal Response to Different Meal Types: A Randomized Crossover Study
Marie Møller Jensen1, Hanne Pedersen1,2, Kim Katrine Bjerring Clemmensen1
1Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Clinical Research, Herlev, Denmark.
The Journal of Nutrition
|January 12, 2022
Summary
The wireless motility capsule (WMC) effectively measures gastrointestinal transit. A standardized mixed meal significantly delayed gastric emptying compared to a SmartBar, demonstrating WMC
Area of Science:
- Gastroenterology and Metabolic Research
- Noninvasive Diagnostic Techniques
Background:
- The wireless motility capsule (WMC) offers a noninvasive, radiation-free method for assessing gastrointestinal transit.
- WMC has potential applications in metabolic research, particularly for standardized mixed meal tolerance tests.
Purpose of the Study:
- To evaluate gastrointestinal transit using WMC after consuming a SmartBar versus a standardized mixed meal.
- To compare postprandial plasma concentrations of metabolites and gastrointestinal hormones, and subjective appetite.
Main Methods:
- A crossover study involving 14 healthy participants comparing SmartBar and standardized mixed meal ingestion.
- Wireless motility capsule (WMC) deployment post-ingestion to measure gastric emptying and whole gut transit.
- Analysis of blood samples for gastrointestinal hormones and metabolites, with gastric emptying time as the primary outcome.
Main Results:
- Gastric emptying time was significantly longer (98 min) after the standardized mixed meal compared to the SmartBar (P < 0.001).
- Postprandial increases in triglycerides, glucose-dependent insulinotropic polypeptide, and peptide YY were significantly greater with the standardized mixed meal.
Conclusions:
- The WMC is suitable for evaluating gastrointestinal transit in conjunction with a standardized mixed meal in healthy individuals.
- The standardized mixed meal prolonged gastric emptying, but did not affect small bowel, colon, or whole gut transit times compared to the SmartBar.
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