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Author Spotlight: Epigenetic Modifications and Metabolic Rewiring as Targets for Cancer Therapy
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Author Spotlight: Epigenetic Modifications and Metabolic Rewiring as Targets for Cancer Therapy

Published on: October 18, 2024

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Histone demethylase JMJD1A in cancer progression and therapeutic resistance

Hee-Young Jeon1,2, Hyunju Ryu1,2, Majid Pornour1,2

  • 1Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, Maryland, USA.

Molecular Carcinogenesis
|January 12, 2022
PubMed

Insights

JMJD1A, a histone demethylase, activates gene transcription by removing repressive marks. Upregulated in cancer, targeting JMJD1A offers a potential anticancer therapy by repressing oncogenic factors.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Cancer Biology

Background:

  • JMJD1A (lysine demethylase 3A) is a Jumonji C family histone demethylase.
  • It removes H3K9me1/2 marks, activating gene transcription.
  • JMJD1A is crucial for spermatogenesis, metabolism, sex determination, and stem cell activity.

Purpose of the Study:

  • Investigate the role of JMJD1A in cancer development and progression.
  • Explore JMJD1A's epigenetic regulation of oncogenic transcription factors.
  • Evaluate JMJD1A as a potential therapeutic target for cancer.

Main Methods:

  • Analysis of JMJD1A expression in various cancer types.
  • Investigating JMJD1A's regulation at transcriptional, post-transcriptional, and post-translational levels.
  • Assessing the impact of JMJD1A on key oncogenic transcription factors (e.g., c-Myc, AR, ER, β-catenin).

Main Results:

  • JMJD1A is upregulated in multiple cancers, promoting tumorigenesis and therapeutic resistance.
  • JMJD1A epigenetically regulates critical transcription factors involved in cancer.
  • Expression and activity of JMJD1A are controlled by multiple regulatory mechanisms in cancer cells.

Conclusions:

  • JMJD1A plays a significant oncogenic role in various cancers.
  • Targeting JMJD1A may offer a novel therapeutic strategy by inhibiting key cancer-driving transcription factors.
Keywords:
JMJD1AKDM3Acancer progressionepigeneticshistone demethylaseprostate cancertranscriptional regulation

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